Correlation between oxidative stress and clopidogrel drug in Iraqi patients with coronary artery disease

Background: Coronary Artery Disease (CAD) is one of the largest causes mortality worldwide. Clopidogrel, antiplatelet drug, has been widely used for management CAD. The current study aimed to investigate effect clopidogrel on oxidative stress in CAD patients. Methods: One hundred patients, who were followed-up 5 days after receiving clopidogrel, and 50 healthy volunteers included this study. Parameters include catalase (CAT), total antioxidant capacity (TAC), oxidant (TOC), protein, albumin, globulins determined before treatment with clopidogrel. Results: CAT, TAC, Tp significantly decreased (P<0.0001) patients compared control levels these parameters returned increase However, TOC level was markedly increased decrease treating Receiver operating characteristic curve showed that CAT gave a higher sensitivity (68-73%) specificity (72%) as an indicator monitoring progression. Conclusion: activity TAC response which helpful reduce risk through scavenging oxidants formation. These results also present predictor variable action.